#REVISIONS NEXT STAGE TRIAL#

#REVISIONS NEXT STAGE TRIAL#

To date, no randomized controlled trial has compared the effectiveness of the one- and two-stage revision procedures. The optimal treatment strategy for the management of deep prosthetic knee infection remains controversial. It might also be a more cost-effective approach. Besides the reduced number of surgical procedures for the patient, the one-stage procedure may be associated with a shorter overall time in hospital, reduced duration of postoperative antibiotic use, and quicker mobilization. For these reasons and though still less commonly used compared to the two-stage revision strategy, the one-stage strategy is an attractive alternative option. However, this revision strategy is associated with long periods of hospitalization, lengthy functional impairment, and high health service costs. The two-stage revision strategy has evolved as the gold standard and preferred procedure for treating PJI of the knee. Most people will receive a one-stage or two-stage revision. Options include: debridement, treatment with antibiotics and retention of the prosthesis one-stage revision two-stage revision resection arthroplasty or arthrodesis or amputation as a last resort. Cure of PJI is not possible by antibiotic treatment alone in the majority of cases and surgical treatment is required. One of the most serious complications of total knee arthroplasty (TKA) is deep periprosthetic joint infection (PJI). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. The views expressed in this article are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This article presents independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research program (RP-PG-1210-12005). Received: NovemAccepted: FebruPublished: March 11, 2016Ĭopyright: © 2016 Kunutsor et al.

PLoS ONE 11(3):Įditor: Heiner Baur, Bern University of Applied Sciences, SWITZERLAND Citation: Kunutsor SK, Whitehouse MR, Lenguerrand E, Blom AW, Beswick AD, INFORM Team (2016) Re-Infection Outcomes Following One- And Two-Stage Surgical Revision of Infected Knee Prosthesis: A Systematic Review and Meta-Analysis.

Revisions next stage